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Showing 18 of 18 papers in Medicine & Physiology

On the possibility of using 3-(3,4-dihydroxyphenyl)alanine (DOPA) as a carrier of radioisotopes to melanoma

Unknown
1965 SovietRxiv: ru-196501.59218

This study examines whether 3-(3,4-dihydroxyphenyl)alanine, DOPA, can serve as a selective carrier of radioisotopes into melanoma tissue, based on its role in melanogenesis and its expected incorporation into melanoproteins. The authors synthesized DOPA labeled with carbon-14 from glycine-2C14 throu…

Corrections to the Article Keioside, a New Flavonoglycoside from the Far Eastern Lily of the Valley (Convallaria keiskei Miq.) (DAN, Vol. 158, No. 4, 1964)

Unknown
1965 SovietRxiv: ru-196501.28233

This paper concerns the evaluation of mexamine as a radioprotective agent within the field of biophysics. Based on the available translated text, the study is presented as an estimation of the compound’s protective efficiency against radiation, but no details of experimental design, measurements, or…

ORGANOPHOSPHORUS COMPOUNDS

B. A. Arbuzov, A. O. Vizel', I. V. Zaikonnikova, I. A. Studentsova, V. G. Dunaev, M. A. Zvereva, K. M. Ivanovskaya
1965 SovietRxiv: ru-196501.14198

This study examines low-toxicity organophosphorus compounds whose biological activity is not primarily attributable to cholinesterase inhibition. New phosphacyclopentane derivatives were synthesized from 1-oxo-1-bromo-3-methylphosphacyclopentane and evaluated in mice by toxicity, duration of lateral…

Structure and Anesthetic Action of Esters of Aminocarbinols

E. M. Cherkasova, A. A. Balandin
1964 SovietRxiv: ru-196401.68397

This paper examines structure, activity relationships in aliphatic aromatic aminocarbinol esters as local anesthetics. Drawing on accumulated synthetic and pharmacological data, the authors compare effects of chain length, branching, stereoisomeric form, acyl group, nitrogen substituent, and aliphat…

Antiradical Activity and Radioprotective Properties of Inhibitors of Free-Radical Reactions

E. V. Burlakova, V. D. Gaintseva, L. V. Slepukhina, N. G. Khrapova, N. M. Emanuel'
1964 SovietRxiv: ru-196401.15603

This study examines whether inhibitors of free-radical chain reactions can act as radioprotective agents by accepting radicals formed in organisms after irradiation. A series of sterically hindered phenols, amino derivatives, polyphenols, and substituted hydroxypyridines were administered to mice be…

Erycordin and Desglucoerycordin – New Cardiac Glycosides

Unknown
1962 SovietRxiv: ru-196201.78722

This study characterizes erycordin, a previously undescribed cardiac glycoside isolated from the herb of Erysimum cheiranthoides, and its related monoglycoside desglucoerycordin. The authors use enzymatic and chemical hydrolysis, acetylation, oxidation, chromatography, elemental analysis, molecular …

Tuberculostatic Properties of a Mixed Thiosemicarbazone Guanylhydrazone of 1,3-Indandione, a Representative of a New Type of Antituberculosis Agents

A. P. Veveris, S. K. Germane, M. A. Alberta, G. A. Grigalinovich,
1962 SovietRxiv: ru-196201.51484

This study evaluates thiogin, the hydrochloride salt of the mixed thiosemicarbazone guanilhydrazone of indandione-1,3, as a representative of a proposed new class of antituberculosis agents active against drug-resistant mycobacteria. Using in vitro serial dilution assays and in vivo experiments in g…

On the Antituberculosis Activity of Thiosulfo Acid Esters

B. G. Boldyrev, T. S. Ginzburg, and R. O. Drabkina
1957 SovietRxiv: ru-195701.65779

This study examines the antitubercular activity of alkyl esters of alkanethiosulfonic acids and alkyl esters of benzenethiosulfonic acid and its derivatives, compounds whose activity against Mycobacterium tuberculosis had been little investigated. Using in vitro assays on a virulent human-type tuber…