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The article proposes a general computer based method for predicting disease courses when reliable mechanistic models are unavailable. It represents case histories as sequences of numbered clinical states and stores observed disease variants in a finite directed random graph with statistically estima…
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This paper describes a digital computer experiment modeling the spread of a large influenza outbreak across 128 major Soviet cities connected by an approximated transportation network. The model uses a system of epidemic equations incorporating city populations, intercity travel, duration of illness…
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This study examines whether 3-(3,4-dihydroxyphenyl)alanine, DOPA, can serve as a selective carrier of radioisotopes into melanoma tissue, based on its role in melanogenesis and its expected incorporation into melanoproteins. The authors synthesized DOPA labeled with carbon-14 from glycine-2C14 throu…
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This paper concerns the evaluation of mexamine as a radioprotective agent within the field of biophysics. Based on the available translated text, the study is presented as an estimation of the compound’s protective efficiency against radiation, but no details of experimental design, measurements, or…
B. A. Arbuzov, A. O. Vizel', I. V. Zaikonnikova, I. A. Studentsova, V. G. Dunaev, M. A. Zvereva, K. M. Ivanovskaya
This study examines low-toxicity organophosphorus compounds whose biological activity is not primarily attributable to cholinesterase inhibition. New phosphacyclopentane derivatives were synthesized from 1-oxo-1-bromo-3-methylphosphacyclopentane and evaluated in mice by toxicity, duration of lateral…
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E. M. Cherkasova, A. A. Balandin
This paper examines structure, activity relationships in aliphatic aromatic aminocarbinol esters as local anesthetics. Drawing on accumulated synthetic and pharmacological data, the authors compare effects of chain length, branching, stereoisomeric form, acyl group, nitrogen substituent, and aliphat…
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E. V. Burlakova, V. D. Gaintseva, L. V. Slepukhina, N. G. Khrapova, N. M. Emanuel'
This study examines whether inhibitors of free-radical chain reactions can act as radioprotective agents by accepting radicals formed in organisms after irradiation. A series of sterically hindered phenols, amino derivatives, polyphenols, and substituted hydroxypyridines were administered to mice be…
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This study characterizes erycordin, a previously undescribed cardiac glycoside isolated from the herb of Erysimum cheiranthoides, and its related monoglycoside desglucoerycordin. The authors use enzymatic and chemical hydrolysis, acetylation, oxidation, chromatography, elemental analysis, molecular …
A. P. Veveris, S. K. Germane, M. A. Alberta, G. A. Grigalinovich,
This study evaluates thiogin, the hydrochloride salt of the mixed thiosemicarbazone guanilhydrazone of indandione-1,3, as a representative of a proposed new class of antituberculosis agents active against drug-resistant mycobacteria. Using in vitro serial dilution assays and in vivo experiments in g…
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B. G. Boldyrev, T. S. Ginzburg, and R. O. Drabkina
This study examines the antitubercular activity of alkyl esters of alkanethiosulfonic acids and alkyl esters of benzenethiosulfonic acid and its derivatives, compounds whose activity against Mycobacterium tuberculosis had been little investigated. Using in vitro assays on a virulent human-type tuber…